ADENOVIRUS-MEDIATED DELIVERY OF BFGF SMALL INTERFERING RNA INCREASES LEVELS OF CONNEXIN 43 IN THE GLIOMA CELL LINE, U251

Adenovirus-mediated delivery of bFGF small interfering RNA increases levels of connexin 43 in the glioma cell line, U251

Abstract Background bFGF is an important growth factor for glioma cell proliferation Quad Canes and invasion, while connexin 43 is implicated in the suppression of glioma growth.Correspondingly, gliomas have been shown to have reduced, or compromised, connexin 43 expression.Methods In this study, a bFGF-targeted siRNA was delivered to the glioma ce

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Kdm4d mutant mice show impaired sperm motility and subfertility

Regulation of gene expression through histone modifications underlies cell homeostasis and differentiation.Kdm4d and Kdm4dl exhibit a high degree of similarity and demethylate H3K9me3.However, the physiological functions of these proteins remain unclear.In Push Along Toy this study, we generated Kdm4dl mutant mice and found that Kdm4dl was dispensa

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